Does Combined Medical and Surgical Treatment Improve Perianal Fistula Outcomes in Patients With Crohn’s Disease? A Systematic Review and Meta-Analysis

The optimal treatment of perianal fistulizing Crohn's disease [PFCD] is unknown. We performed a systematic review with meta-analysis to compare combined surgical intervention and anti-tumour necrosis factor [anti-TNF] therapy [combined therapy] vs either therapy alone.