溶瘤病毒
牛痘
病毒
癌症研究
病毒学
CD8型
胰腺导管腺癌
医学
腺癌
胰腺癌
功能(生物学)
生物
癌症
免疫系统
免疫学
内科学
基因
细胞生物学
重组DNA
生物化学
作者
Wei Wei,Linqing Tian,Xiaoyan Zheng,Liang Zhong,Yuan Chen,Hongyan Dong,Guibing Zhang,Shibing Wang,Xiangmin Tong
出处
期刊:OncoImmunology
[Informa]
日期:2024-02-27
卷期号:13 (1)
标识
DOI:10.1080/2162402x.2024.2322173
摘要
Pancreatic ductal adenocarcinoma (PDAC) is currently difficult to treat, even when therapies are combined with immune checkpoint blockade (ICB). A novel strategy for immunotherapy would be to maximize the therapeutic potential of oncolytic viruses (OVs), which have been proven to engage the regulation of tumor microenvironment (TME) and cause-specific T-cell responses. To boost tumor sensitivity to ICB therapy, this study aimed to investigate how glutathione peroxide 4 (GPX4)-loaded OVs affect CD8+ T cells and repair the immunosuppressive environment. Here, we successfully constructed a novel recombinant oncolytic vaccinia virus (OVV) encoding the mouse GPX4 gene. We found the OVV-GPX4 effectively replicated in tumor cells and prompted the expression of GPX4 in T cells. Our research indicated that OVV-GPX4 could reshape the TME, rectify the depletion of CD8+T cells, and enhance the antitumor effects of ICB therapy.
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