Asymmetric palladium-catalyzed decarboxylative [3+2] cycloaddition: straightforward construction of chiral spiro-heterocyclic scaffolds

A novel asymmetric Pd-catalyzed decarboxylative [3+2] cycloaddition of vinylethylene carbonates and α, β-unsaturated pyrazolones has been developed to afford the high functionalized tetrahydrofuran-fused spiro-heterocyclic skeletons with excellent stereoselectivity. A diverse...