启动(农业)
细胞毒性T细胞
CD8型
记忆T细胞
T细胞
免疫学
生物
抗原
神经科学
细胞生物学
心理学
免疫系统
遗传学
体外
植物
发芽
作者
Verena van der Heide,Bennett Davenport,Beatrice Cubitt,Vladimir Roudko,Daniel Choo,Étienne Humblin,Kevin Jhun,Krista Angeliadis,Travis Dawson,Gláucia C. Furtado,Alice O. Kamphorst,Rafi Ahmed,Juan Carlos de la Torre,Dirk Homann
标识
DOI:10.1101/2024.01.22.576725
摘要
Generation of functional CD8 + T cell memory typically requires engagement of CD4 + T cells. However, in certain scenarios, such as acutely-resolving viral infections, effector (T E ) and subsequent memory (T M ) CD8 + T cell formation appear impervious to a lack of CD4 + T cell help during priming. Nonetheless, such "helpless" CD8 + T M respond poorly to pathogen rechallenge. At present, the origin and long-term evolution of helpless CD8 + T cell memory remain incompletely understood. Here, we demonstrate that helpless CD8 + T E differentiation is largely normal but a multiplicity of helpless CD8 T M defects, consistent with impaired memory maturation, emerge as a consequence of prolonged yet finite exposure to cognate antigen. Importantly, these defects resolve over time leading to full restoration of CD8 + T M potential and recall capacity. Our findings provide a unified explanation for helpless CD8 + T cell memory and emphasize an unexpected CD8 + T M plasticity with implications for vaccination strategies and beyond.
科研通智能强力驱动
Strongly Powered by AbleSci AI