氧化铈
活性氧
化学
缺血
超氧化物歧化酶
神经保护
超氧化物
小胶质细胞
再灌注损伤
医学
神经炎症
药理学
氧化应激
生物化学
内科学
炎症
免疫学
酶
催化作用
作者
Qiang Zhang,Zihao Liu,Bo Li,Liuhua Mu,Kai Shuang,Yijia Xiong,Jiahui Cheng,Jia Zhou,Zheng Xiong,Lingling Zhou,Lixian Jiang,Jueheng Wu,Xiaojun Cai,Yuanyi Zheng,Wenxian Du,Yuehua Li,Donghui Zhang
标识
DOI:10.1002/adhm.202303027
摘要
Effective neuroprotective agents are required to prevent neurological damage caused by reactive oxygen species (ROS) generated by cerebral ischemia-reperfusion injury (CIRI) following an acute ischemic stroke. Herein, it is aimed to develop the neuroprotective agents of cerium oxide loaded with platinum clusters engineered modifications (Ptn -CeO2 ). The density functional theory calculations show that Ptn -CeO2 could effectively scavenge ROS, including hydroxyl radicals (·OH) and superoxide anions (·O2- ). In addition, Ptn -CeO2 exhibits the superoxide dismutase- and catalase-like enzyme activities, which is capable of scavenging hydrogen peroxide (H2 O2 ). The in vitro studies show that Ptn -CeO2 could adjust the restoration of the mitochondrial metabolism to ROS homeostasis, rebalance cytokines, and feature high biocompatibility. The studies in mice CIRI demonstrate that Ptn -CeO2 could also restore cytokine levels, reduce cysteine aspartate-specific protease (cleaved Caspase 3) levels, and induce the polarization of microglia to M2-type macrophages, thus inhibiting the inflammatory responses. As a result, Ptn -CeO2 inhibits the reperfusion-induced neuronal apoptosis, relieves the infarct volume, reduces the neurological severity score, and improves cognitive function. Overall, these findings suggest that the prominent neuroprotective effect of the engineered Ptn -CeO2 has a significant neuroprotective effect and provides a potential therapeutic alternative for CIRI.
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