自噬
米曲霉
液泡
ATG8型
细胞生物学
粒体自噬
过氧化物酶体
化学
蛋白质降解
生物化学
生物
酶
基因
细胞质
细胞凋亡
作者
Joichiro Nishio,Yoshiaki Takahashi,Masahiro Kasahara,Yoichi Takeda,Takashi Kikuma
出处
期刊:FEBS Letters
[Wiley]
日期:2023-02-02
卷期号:597 (5): 608-617
标识
DOI:10.1002/1873-3468.14589
摘要
Autophagy is classified into nonselective and selective autophagy, depending on the specificity of substrate degradation. In the filamentous fungus Aspergillus oryzae, selective autophagy, which includes pexophagy and mitophagy, has been observed. However, the molecular mechanism underlying selective autophagy in filamentous fungi remains unclear. Here, we identified a novel protein that interacts with the autophagy-related protein Atg8 in A. oryzae, named AoAtg8-interacting protein A (AeiA). AeiA was localized to AoAtg8-positive autophagic membrane structures and peroxisomes. Moreover, peroxisomal trafficking into the vacuole was reduced in AeiA disruptants. Taken together, AeiA is a novel selective autophagy-related protein that contributes to pexophagy in A. oryzae.
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