烯烃
化学
卡宾
催化作用
乙烯基
咪唑
光催化
药物化学
组合化学
光化学
有机化学
激进的
光催化
作者
Yi-Xiong Dong,Chun-Lin Zhang,Zhong‐Hua Gao,Song Ye
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-01-26
卷期号:25 (5): 855-860
被引量:17
标识
DOI:10.1021/acs.orglett.3c00006
摘要
The iminoacylation of alkenes via photoredox N-heterocyclic carbene catalysis is developed with the employment of alkene-tethered α-imino-oxy acids and acyl imidazoles. The corresponding substituted 3,4-dihydro-2H-pyrroles were afforded in moderate to good yields with good to high diastereoselectivities in most cases. The reaction involves the 5-exo-trig radical cyclization of an alkene-tethered iminyl radical and the following coupling with a ketyl radical from acyl imidazole under NHC catalysis.
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