Axonal Transport Defects in Retinal Ganglion Cell Diseases

For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transportAxonal transports defects usually precede axonal degenerationAxonal degeneration and RGC loss in disease models. To date, the main causes of axonal transportAxonal transports defects have not been fully understood. Therefore, elucidation of the mechanismsMechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degenerationAxonal degeneration with a focus on axonal transportAxonal transports.