Effect of Ganoderma lucidum on physiological indices and gut microflora: A review

Ganoderma lucidum is commonly known as a traditional medicinal mushroom with a pharmacological compound that is regarded as nutraceutical for improving health and treating disease. It contains a huge amount of polysaccharides with molecular weights ranging from thousands to millions. A recent study indicates that Ganoderma lucidum has many pharmacological activities such as anti-tumor, hepatoprotective, and anti-inflammatory and exerts other bioactivities such as gut microbiome regulation. This review works on the potential of nutraceutical supplements to mitigate host health problems by regulating the gut microbiome in humans, regulating enzyme production and changes in biochemical parameters, and altering hematological parameters. The gut microbiome plays an essentially active role in diverse physiological processes such as digestion, and immune defense, and more recently has been shown as a stress regulation factor. Modulation of the gut microbiome may be an effective therapy for reducing many health problems. The findings from many research suggested that Ganoderma lucidum may have the capability to modulate the gut microbiome by increasing the growth of beneficial bacteria and reducing the growth of pathogenic bacteria. This review aims to report the effect of Ganoderma lucidum on human gut microbiome ecosystem modulation and also involved in the alteration of biochemical parameters and maintaining blood profile.