安普克
血脂异常
炎症
医学
激活剂(遗传学)
二甲双胍
疾病
卡格列净
生物利用度
内分泌学
内科学
药理学
蛋白激酶A
2型糖尿病
糖尿病
激酶
生物
细胞生物学
受体
作者
Emily Day,Leah Townsend,Sonia Rehal,Battsetseg Batchuluun,Qianqian Wang,Monica Morrow,Ran Lu,Lucie Lundenberg,Jia Lu,E Desjardins,Amogelang R. Raphenya,A. T. G. McArthur,Meryl J. Fullerton,Gregory R. Steinberg
标识
DOI:10.1016/j.cjca.2023.06.366
摘要
Atherosclerotic cardiovascular disease (CVD) is the leading cause of death in the developed world and is characterized by both chronic low-grade inflammation and dyslipidemia. AMPK inhibits cholesterol synthesis and inflammation; however, the importance of therapeutic targeting is not known as to date only compounds that indirectly activate the kinase and have multiple other molecular targets and metabolic effects (i.e. metformin, canagliflozin, salsalate) or have low oral and cellular bioavailability (i.e. A769662) have been examined.
科研通智能强力驱动
Strongly Powered by AbleSci AI