Thiazole ring- the antimicrobial, anti-inflammatory, and anticancer active scaffold

Thiazole ring is one of the most important heterocycle scaffolds in organic and medicinal chemistry due to this scaffold being the backbone of numerous drugs and their significant activities against various diseases have made it one of the best candidates for industrial production. According to the literature, the number of drugs that have this ring on their structures is increasing. In fact, drugs containing thiazole scaffold have taken a significant share in the last decade, which reached its maximum number of 8 drugs in 2019. Objective: In This current review, we focus on essential advances of antimicrobial, anti-inflammatory, and anticancer activities of structures containing thiazole scaffold and various groups’ effects on this scaffold against the broad spectrum of bacterial strains, fungal strains, inflammatory cells, and cancer cells. Also, we analyzed and investigated thiazole hybrids with potential antimicrobial, anti-inflammatory, and anticancer activities. Results: More than 100 research articles were found, we selected about 100 research articles from 2014 to 2022 that had outstanding results.