Cisplatin SERS Detection Based on the Binding of Sulfhydryl Groups

Cisplatin, a first-line anti-cancer drug, is widely utilized in clinical practice. Its anti-cancer mechanism involves DNA binding in the nucleus, leading to inhibition of cell division or induction of apoptosis. However, as heavy metal, platinum tends to accumulate in the body during metabolism and often results in nephrotoxicity, ototoxicity, and neurotoxicity. Therefore, developing an accurate cisplatin detection method is valuable for personalized treatment planning. In this study, we developed a novel p-amino thiophene (PATP) reaction-mediated surface-enhanced Raman scattering (SERS) assay for cisplatin detection. The Raman intensity of v (C-S) is linearly correlated with cisplatin concentration. This method is low-cost and convenient with high precision