Cistadesertosides B−E, Four New Diastereomeric Lignan Glycosides from the Stems of Cultural Cistanche deserticola in Tarim Desert

Abstract Four previously undescribed diastereomeric lignan glycosides, namely cistadesertosides B−E ( 1 – 4 ) were isolated from the stems of cultural Cistanche deserticola in Tarim desert. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, HR‐ESI‐MS, 1D and 2D NMR, circular dichroism (CD) data and chemical degradation. The in vitro anti‐inflammatory activity of the isolates was also investigated. It showed that compounds 3 and 4 exhibited potential effects with IC 50 values of 21.17 μM and 26.97 μM, respectively (positive control quercetin, IC 50 , 10.01 μM).