硅烷
硅氢加成
区域选择性
化学
马尔科夫尼科夫法则
烯丙基重排
共轭体系
配体(生物化学)
电泳剂
有机化学
催化作用
药物化学
组合化学
硅烷
聚合物
受体
生物化学
作者
Xiaoyu Wu,Wei Liu,Liqun Yang,Yue Wang,Tianwen Liu,Yuan Yao,Yan Lu,Zhaoguo Zhang
标识
DOI:10.1002/cjoc.202300407
摘要
Comprehensive Summary With the increasing demand for homoallylic silanes and allylic silanes, the highly efficient and regioselective hydrosilylations of conjugated dienes are urgently needed. Herein, we developed a Ni‐catalyzed regiodivergent hydrosilylation of aromatic conjugated dienes by adjusting the temperature and ligands. Under low temperature (–30 °C), an eternal‐ligand‐free system (Ni/ t ‐BuOK) can efficiently facilitate the 3,4‐ anti ‐Markovnikov hydrosilylation to provide homoallylic silanes via electrophilic activation process; under room temperature (25 °C), a ligand‐controlled system (Ni/ t ‐BuOK/PPh 3 ) can eventuate the 3,4‐Markovnikov hydrosilylation to produce allylic silanes via Chalk‐Harrod process. Both systems are compatible with various conjugated dienes and primary silanes in excellent yields and regioselectivities.
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