中胚层
细胞生物学
诱导多能干细胞
生物
节的
干细胞
胚胎干细胞
解剖
遗传学
基因
作者
Amitesh Panda,Thi Xuan Ai Pham,Sherif Khodeer,Vincent Pasque
出处
期刊:Methods in molecular biology
日期:2023-01-01
标识
DOI:10.1007/7651_2023_483
摘要
The human extraembryonic mesoderm (EXM) is an important tissue in the postimplantation embryo which is specified before gastrulation in primates but not in rodents. EXM is mesenchymal and plays an important role in embryogenesis, including early erythropoiesis, and provides mechanical support to the developing embryo. Recently, it has been shown that self-renewing extraembryonic mesoderm cells (EXMCs) can be modeled in vitro by using human naive pluripotent stem cells. Here, we present a detailed step-by-step protocol to induce EXMCs from naive pluripotent stem cells in vitro.
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