Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

Main text(Cell Reports 38, 110513, March 15, 2022; 1–14.e5)Figure 7. CypA inhibits Cyld-mediated, K63-linked ILK deubiquitination (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Main text(Cell Reports 38, 110513, March 15, 2022; 1–14.e5) (Cell Reports 38, 110513, March 15, 2022; 1–14.e5) Delicate regulation of IL-1β-mediated inflammation by cyclophilin AYang et al.Cell ReportsMarch 15, 2022In BriefYang et al. show that CypA enhances mature IL-1β production, leading to cytokine-mediated lung injury in the inflammation-activation phase. In addition, CypA promotes redundant pro-IL-1β degradation and EMT-mediated lung repair in the inflammation-resolution phase. These data reveal that IL-1β-mediated inflammation is precisely regulated by CypA. Full-Text PDF Open Access