BaO‐Catalyzed α‐Deuteration of Ketones, Sulfones, Sulfoxides, and Nitriles

Abstract Herein a facile methodology of α‐deuterating ketones, sulfoxides, sulfones and nitriles using catalytic BaO was developed. The protocol allowed high d ‐incorporation in a single‐run with broad functional group tolerance and was scalable and applicable in preparing exemplary bioactive ketone candidates.