Probiotics armored with metal-phenolic network-based nanocoatings for gut microbiome modulation

Oral delivery of living probiotics to the microbiome is a promising strategy for the treatment of gut disorders. However, a harsh gastrointestinal (GI) microenvironment greatly limits their therapeutic outcomes. Encapsulating living probiotics with biomaterial-based nanocoatings can not only protect these probiotics from the assaults of the antibiotics and the GI microenvironment but also facilitate the retention of probiotics in the GI tract. This preview highlights a recent study regarding a metal-phenolic network-based single-cell nanocoating composed of FeIII and tannic acid (termed nanoarmor) that can protect probiotics from the action of antibiotics. Oral delivery of living probiotics to the microbiome is a promising strategy for the treatment of gut disorders. However, a harsh gastrointestinal (GI) microenvironment greatly limits their therapeutic outcomes. Encapsulating living probiotics with biomaterial-based nanocoatings can not only protect these probiotics from the assaults of the antibiotics and the GI microenvironment but also facilitate the retention of probiotics in the GI tract. This preview highlights a recent study regarding a metal-phenolic network-based single-cell nanocoating composed of FeIII and tannic acid (termed nanoarmor) that can protect probiotics from the action of antibiotics.