促红细胞生成素肝细胞(Eph)受体
以法林
EPH受体A2
癌症研究
乳腺癌
癌症
受体酪氨酸激酶
生物
医学
受体
内科学
作者
Iason Psilopatis,Eleni Souferi-Chronopoulou,Kleio Vrettou,Constantinos Troungos,Stamatios Theocharis
标识
DOI:10.3390/ijms232315275
摘要
Breast cancer (BC) is the most common malignant tumor in women. Erythropoietin-producing hepatocellular receptors (EPHs), receptor tyrosine kinases binding the membrane-bound proteins ephrins, are differentially expressed in BC, and correlate with carcinogenesis and tumor progression. With a view to examining available therapeutics targeting the EPH/ephrin system in BC, a literature review was conducted, using the MEDLINE, LIVIVO, and Google Scholar databases. EPHA2 is the most studied EPH/ephrin target in BC treatment. The targeting of EPHA2, EPHA10, EPHB4, ephrin-A2, ephrin-A4, as well as ephrin-B2 in BC cells or xenograft models is associated with apoptosis induction, tumor regression, anticancer immune response activation, and impaired cell motility. In conclusion, EPHs/ephrins seem to represent promising future treatment targets in BC.
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