Multi-Gram Scale Synthetic Routes to Solvent-Free Common Secondary Dialkylphosphines and Chlorodialkylphosphines

Secondary dialkylphosphines and chlorodialkylphosphines are some of the most common starting points in ligand synthesis, however sourcing these synthons can be troublesome. In this paper we present scalable synthetic routes to the iso-propyl, tert-butyl and cyclohexyl derivatives, starting either from PCl3 or HP(O)(OEt)2. Detailed experimental procedures are given to allow for ease of synthesis.