Vision Loss as a Rising Global Health Challenge: Comprehensive Analysis of High Fasting Plasma Glucose Burden and Projections to 2035

ABSTRACT Background Vision loss caused by high fasting plasma glucose (HFG) is a growing global health concern. This study evaluates the global and regional burden of HFG‐attributable vision loss from 1990 to 2021 and projects future trends through 2035. Methods Using Global Burden of Disease (GBD) 2021 data, we assessed disability‐adjusted life years (DALYs) across 204 countries, stratified by gender, age, and Sociodemographic Index (SDI). Temporal trends were analysed using Joinpoint regression, and projections were made using ARIMA modelling. Results Global DALYs due to HFG‐related vision loss rose from 613,694 in 1990 to 1,674,401 in 2021. South Asia and Sub‐Saharan Africa experienced the highest burdens, especially among females and older adults. Although age‐standardized DALY rates slightly declined globally, they remained elevated in low‐SDI regions. Projections suggest a continued increase through 2035. Conclusions The burden of vision loss due to HFG is rising, with stark regional and demographic disparities. Urgent, targeted interventions are needed to reduce this growing health burden, particularly in low‐SDI areas and among high‐risk populations.