Integrated multi-omics analysis identifies TLR4-mediated mechanisms in ATBC-induced ovarian dysfunction and female infertility: A network toxicology, transcriptomic, and Mendelian randomization study

This first multi-omics investigation of ATBC reproductive toxicity uncovers TLR4 as a critical mediator of ovarian dysfunction and infertility through inflammation-related pathways. Our findings provide novel mechanistic insights and suggest TLR4 modulation as a potential therapeutic strategy for chemical-induced reproductive disorders.