阳极
阴极
电解
硝酸盐
级联
化学
材料科学
无机化学
电极
有机化学
电解质
色谱法
物理化学
作者
Ouwen Peng,Qikun Hu,Mengtian Jin,Mengyao Su,Jia Liu,Bo Li,Shibo Xi,Chun Cheng,Kian Ping Loh
标识
DOI:10.1038/s41467-025-61186-2
摘要
Oximes are crucial intermediates in the production of polymers and pharmaceuticals. Conventional synthesis methods, involving the hydrogenation of nitrogen oxides and nucleophilic addition of hydroxylamine to carbonyl compounds, are energy-intensive and hazardous. Here, we report an economical and sustainable electrosynthesis route to oximes using hydroxyl compounds and nitrate in an anode-cathode cascade electrolyzer. In this system, hydroxyl compounds are first dehydrogenated to ketones at a cobalt oxyhydroxide anode, followed by the subsequent co-reduction of ketones with nitrate at a Cu-substituted Fe3C cathode to form oximes. The cascade electrolyzer exhibits robust performance over 72 h at 2.8 V, achieving a high pyruvatoxime yield of 2.61 mmol cm-2 h-1 with a Faradaic efficiency of 101%. This versatile method accommodates diverse feedstocks, enabling the production of various relevant commodities. Process modeling and techno-economic analysis confirm the viability and cost-effectiveness of this innovative approach, offering a more sustainable pathway to essential chemical intermediates.
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