Iron‐Mediated Direct Ortho ‐ Nitration of Anilides and Aromatic Sulfonamides under Aerobic Oxidation Conditions.

Abstract Direct ortho ‐nitration of anilides and aromatic sulfonamides employing inexpensive, nontoxic and readily available iron reagent is described. It is proposed that the aromatic nitration reaction operates through a single electron transfer (SET) mechanism and is effective in the absence of additive. The reaction produced a variety of mono nitrated derivatives with moderate to excellent yields. The reaction provides a practical method for the synthesis of nitro compounds owing to its simple experimental procedure, mild reaction conditions, broad substrate scope and the functional group compatibility.