Synthesis and Structural Studies of O-vanillin Indomethacin Hydrazone and P-vanillin Indomethacin Hydrazone

Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized.For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ).Finally, this hydrazide condensed with o-Vanillin and p-Vanillin to get targeted compounds.Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy.