A novel biocompatible core-shell magnetic nanocomposite based on cross-linked chitosan hydrogels for in vitro hyperthermia of cancer therapy

In this work, the chemical cross-linked interaction between chitosan polymeric chains and synthetic terephthaloyl diisothiocyanate as a cross-linker was accomplished in order to fabricate three dimensional cross-linked chitosan hydrogel. This cross-linked hydrogel with considerable characteristics including high stability and homogeneity in aqueous solution (water) and high porosity was applied as new substrate for generation of new magnetic terephthaloyl thiourea cross-linked chitosan nanocomposite. The features of this new magnetic nanocomposite were characterized by FT-IR, EDX, FE-SEM, TEM and VSM analysis. The Size distribution of nanoparticles according to the size histogram of FE-SEM images was estimated between 30 and 40 nm. The performance of designed magnetic nanocomposite was evaluated by magnetic fluid hyperthermia procedure. Under the alternating magnetic field (AMF), the specific absorption rate (66.92 w·g-1) was determined and as well, its saturation magnetization value was reported 78.43 emu·g-1.