萧条(经济学)
心率变异性
自主功能
自杀意念
医学
内科学
心脏病学
人口
心功能曲线
自主神经系统
贝克抑郁量表
心率
心理学
精神科
心力衰竭
毒物控制
血压
伤害预防
急诊医学
焦虑
经济
宏观经济学
环境卫生
作者
Hsin-An Chang,Chuan Chia Chang,Chih Lun Chen,Terry B.J. Kuo,Ru Band Lu,San Yuan Huang
出处
期刊:Acta Neuropsychiatrica
[Cambridge University Press]
日期:2012-12-01
卷期号:24 (6): 318-327
被引量:45
标识
DOI:10.1111/j.1601-5215.2011.00647.x
摘要
Chang H-A, Chang C-C, Chen C-L, Kuo TBJ, Lu R-B, Huang S-Y. Major depression is associated with cardiac autonomic dysregulation. Objective: Altered cardiac autonomic function has been proposed in patients with major depression (MD), but the results are mixed. Therefore, analyses with larger sample sizes and better methodology are needed. Methods: To examine whether cardiac autonomic dysfunction is associated with MD, 498 unmedicated patients with MD and 462 healthy volunteers, aged 18–65 years, were recruited for a case-control analysis. We used the Hamilton Depression Rating Scale (HAM-D) and the Beck Depression Inventory (BDI) to assess depression severity. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV) parameters. Frequency-domain indices of HRV were obtained. Results: Patients with MD exhibited reduced cardiac vagal control compared to healthy volunteers, and depression severity was negatively correlated with cardiac vagal control. Stratified analyses by suicide ideation revealed more pronounced cardiac vagal withdrawal among MD patients with suicide ideation. Conclusion: This study shows that MD is associated with cardiac autonomic dysregulation, highlighting the importance of assessing HRV in currently depressed patients, given the higher risk for cardiac complications in these individuals. Taking into account that suicidal depressed patients had more adverse patterns of HRV, one might consider the treatment to restore the autonomic function for the patient population having increased susceptibility to autonomic dysregulation.
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