表观遗传学
癌症
医学
后生
时间轴
细胞凋亡
癌症研究
生物
程序性细胞死亡
癌细胞
生物信息学
计算生物学
遗传学
基因
DNA甲基化
基因表达
历史
考古
作者
Alex R. D. Delbridge,Stephanie Grabow,Andreas Strasser,David L. Vaux
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2016-01-29
卷期号:16 (2): 99-109
被引量:572
摘要
The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter these alterations might be effective as anti-cancer strategies. Over the past 30 years, research on the BCL-2-regulated apoptotic pathway has led to the development of small-molecule compounds, known as 'BH3-mimetics', that bind to pro-survival BCL-2 proteins to directly activate apoptosis of malignant cells. This Timeline article focuses on the discovery and study of BCL-2, the wider BCL-2 protein family and, specifically, its roles in cancer development and therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI