Capsaicin pretreatment enhanced the bioavailability of fexofenadine in rats by P-glycoprotein modulation:in vitro,in situandin vivoevaluation

Capsaicin pretreatment significantly enhanced the intestinal absorption and bioavailability of fexofenadine in rats likely by inhibition of P-gp mediated cellular efflux, suggesting that the combined use of capsaicin with P-gp substrates may require close monitoring for potential drug interactions.