异鼠李素
脂肪变性
内分泌学
非酒精性脂肪肝
内科学
罗格列酮
瘦素
脂肪细胞
过氧化物酶体增殖物激活受体
过氧化物酶体
医学
PPAR激动剂
化学
生物
脂肪肝
药理学
受体
肥胖
脂肪组织
槲皮素
疾病
生物化学
抗氧化剂
山奈酚
作者
Yu Zhang,Ming Gu,Wujie Cai,Lamei Yu,Feng Li,Lu Zhang,Qing-qing Zang,Yahui Wang,Dongshan Wang,Hui Chen,Qingchun Tong,Guang Ji,Cheng Huang
摘要
Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused on agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver disease (NAFLD), one of the most challenging medical conditions. Here, we identified that isorhamnetin, a naturally occurring compound in fruits and vegetables and the metabolite of quercetin, is a novel antagonist of PPARγ. Isorhamnetin treatment inhibited the adipocyte differentiation induced by the PPARγ agonist rosiglitazone, reduced obesity development and ameliorated hepatic steatosis induced by both high-fat diet treatment and leptin deficiency. Our results suggest that dietary supplement of isorhamnetin may be beneficial to prevent obesity and steatosis and PPARγ antagonists may be useful to treat hepatic steatosis.
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