The effects of heat treatment on microstructure and mechanical properties of TC4 alloy big bar(?准350 mm) is researched.The results show that a uniformed bimodal microstructure of equiaxed alpha phase and beta phase is found.Equiaxed alpha phase is shape of ellipsoid or short rod.Beta phase is lath.The size of alpha phase and beta phase reduces,and the uniform of alpha phase and beta phase enhances with the increase of annealing temperature,while tensile strength and fracture toughness at room temperature increase with the increase of annealing temperature.