Influence of the conditions of artificial hibernation on the content of ATP, ADP, AMP, cAMF in the blood and liver of rats is studied. It is established, that the entering and stay of animals in the conditions of artificial hibernation is accompanied by a decrease of the content of ADP and P(l). The animal coming out of the condition of artificial hibernation is accompanied by an increase of the content of ATP and cAMP and achievement in twenty-four hours of the level of monitoring values.