The effect of docetaxel combined with epirubicin on local advanced breast cancer

Objective: To investigate the efficacy and toxicity of docetaxel-epirubicin regimen in treating advanced breast cancer.Methods: A retrospective analysis was taken on a total of 63 patiens with advanced breast cancer treated with docetaxel-epirubicin(docetaxel was administered at 75 mg/m2iv d1 and epirubicin was administered at 75 mg/m2iv d1).The treatment was repeated every 21 days at lesat for 2-4 cycles.The efficacy and toxicity were evaluated at the end of each cycle.Results: The total effective rate(CR+PR)was 68.3%,8 cases received CR,35 PR,13 SD and 7 PD.24 months was median time of follow-up,6 cases died,13 cases relapsed and metastasis,44 cases alived.Conclusion: docetaxel-epirubicin regimen as neoadjuvant chemotherapy can shrink tumor size,increase the operation chance and improve the survival rate.