Baseline Trajectories of Drinking Moderate Acamprosate and Naltrexone Effects in the COMBINE Study: BASELINE TRAJECTORIES OF DRINKING IN COMBINE

The COMBINE Study evaluated the effects of acamprosate, naltrexone and the Combined Behavioral Intervention (CBI). In secondary analyses, our goals were to identify trajectories of any drinking prior to randomization, to characterize subjects in these trajectories, and to assess whether pre-randomization trajectories predict drinking outcomes and moderate treatment response.