止血剂
生物相容性
止血
伤口愈合
纳米纤维
体内
纤维素
化学
海绵
血栓弹性成像
生物医学工程
材料科学
血小板
纳米技术
生物化学
外科
医学
有机化学
生物
免疫学
生物技术
植物
作者
E.A. Mohamed,Yi Wang,Philip Crispin,Ailene Fitzgerald,Jane E. Dahlstrom,Suzanne Fowler,David R. Nisbet,Takuya Tsuzuki,Lucy A. Coupland
标识
DOI:10.1002/mabi.202200222
摘要
Many materials have been engineered and commercialized as hemostatic agents. However, there is still a gap in the availability of hemostats that offer biocompatibility and biodegradability in combination with effective hemostatic properties. Cellulose nanofibers are investigated as hemostatic materials with most studies focusing on oxidized cellulose-derived hemostats. The recent studies demonstrate that by optimizing the morphological properties of nonoxidized cellulose nanofibers (CNFs) enhanced hemostasis is achieved. Herein, the hemostatic and wound-healing properties of CNFs with optimized morphology using two forms, gel, and sponge is investigated. In vitro thromboelastometry studies demonstrate that CNFs reduce clotting time by 68% (±SE 2%) and 88% (±SE 5%) in gel and sponge forms, respectively. In an in vivo murine liver injury model, CNFs significantly reduce blood loss by 38% (±SE 10%). The pH-neutral CNFs do not damage red blood cells, nor do they impede the proliferation of fibroblast or endothelial cells. Subcutaneously-implanted CNFs show a foreign body reaction resolving with the degradation of CNFs on histological examination and there is no scarring in the skin after 8 weeks. Demonstrating superior hemostatic performance in a variety of forms, as well as biocompatibility and biodegradability, CNFs hold significant potential for use in surgical and first-aid environments.
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