Endothelial cells secrete small extracellular vesicles to promote neuron endoplasmic reticulum stress injury via miR-146a-5p/Eif4g2 axis in ischemic stroke

Our research clarifies the role of miR-146a-5p-containing sEVs in inducing neuron injury by targeting Eif4g2-mediated ER stress in IS. Additionally, we demonstrated a new mechanism for NBP treating IS. These results clarify the molecular mechanisms of IS pathogenesis and provide perspectives on new therapeutic approaches.