Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: Insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis

Our findings identify a novel role for PDK4 in mediating osimertinib-induced cardiomyocyte necroptosis via MAM formation and mitochondrial calcium overload. Targeting the PDK4-BAP31-FIS1 axis may offer a potential therapeutic strategy to mitigate the cardiotoxic effects of osimertinib.