Transfersomes: a next-generation drug delivery system for topical ocular drug delivery

INTRODUCTION: The eye is a complex organ with several anatomical and physiological barriers that make ocular drug delivery an ongoing challenge. Transfersomes (TFS) are deformable vesicles that have been extensively applied to enhance transdermal drug delivery. However, their application in ocular drug delivery remains largely unexplored. AREAS COVERED: This review highlights the challenges typically associated with ocular drug delivery and emphasizes the inherent properties of TFS that enable them to overcome these challenges. The influence of excipients and critical process parameters on TFS characteristics have been discussed in detail with an emphasis on the fabrication and characterization techniques typically employed for TFS development and optimization. Furthermore, recent studies evaluating the application of TFS in ocular drug delivery have been discussed in depth. EXPERT OPINION: The unique stress-responsive and deformable nature of TFS makes them promising carriers for ocular drug delivery. However, further research in this direction is needed to understand their penetration mechanism and elucidate their potential for sustained and targeted drug delivery to ocular tissues. Moreover, further research is needed to optimize the stability and scalability of TFS to encourage their translation to the market.