Beta-Band Connectivity Alterations as a Predictor for SAINT Outcomes in Treatment-Resistant Depression

target whenever a participant was flagged by the algorithm.The minimum number of SAINT treatment days required (1-5 days) were given to reestablish remission.Results: Twenty-one participants with a mean baseline MADRS score of 29.5 (SD 6.8) entered remission (MADRS 10) the week following treatment with SAINT.All 21 participants who received PCT as indicated by the proprietary algorithm, maintained remission.Over 12 months, participants sustained remission for 85.7% (SD19.7) of the monitoring period, response for 95.3% (SD9.4;MADRS score 50% of baseline) with an average MADRS score of 7.07 (SD 7.1).The time-weighted-average (AUC/time) was 8.0 (SD4.9).On average, participants required 14.9 PCT treatment days over 12 months, with 68.9% of PCT courses consisting of 1-2 days of SAINT.Discussion: This study demonstrates that following initial remission, continuation therapy in response to an algorithmically identified trend toward relapse is effective at maintaining participants in a continuously non-depressed state over a 12-month period.Algorithmically driven PCT with SAINT is a safe approach for chronically preventing relapse with no serious adverse effects.This study also provides evidence that an fMRIgenerated target is durable for at least 12 months.