Construction of chiral γ-lactam scaffolds via asymmetric cascade [3+2] annulation of N-alkoxyacrylamides catalyzed by a chiral-at-metal rhodium complex

An efficient asymmetric cascade [3+2] annulation of N-alkoxyacrylamides with α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium complex has been developed. The enantioenriched γ-lactam derivatives bearing three contiguous tertiary stereocenters...