巨噬细胞极化
巨噬细胞
脂肪细胞
CXCL14型
旁分泌信号
炎症
医学
药理学
化学
癌症研究
内分泌学
内科学
趋化因子
脂肪组织
生物化学
受体
体外
趋化因子受体
作者
Peikun He,Hao Wang,Saibo Cheng,Fang Hu,Lifang Zhang,Weicong Chen,Yuling Xu,Yaxin Zhang,Yuyan Gu,Zhaoyong Li,Yao Jin,Xiaoyu Liu,Yuhua Jia
标识
DOI：10.1016/j.jep.2023.116532
摘要
In summary, our findings suggest that geniposide protects ApoE-/- mice against WD-induced atherosclerosis by inducing M2 polarization of plaque macrophages via enhanced expression of CXCL14 in PVAT. These data provide novel insights into PVAT paracrine function in atherosclerosis and reaffirm geniposide as a therapeutic drug candidate for atherosclerosis treatment.
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(2025-6-4)
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