已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

开阔地 DNA损伤 彗星试验 毒性 抗氧化剂 体内 化学 高架加迷宫 药理学 谷胱甘肽 生物 生物化学 内分泌学 DNA 医学 焦虑 遗传学 有机化学 精神科
作者
Abraão Tiago Batista Guimarães,Ítalo Nascimento Freitas,Nabisab Mujawar Mubarak,Md. Mostafizur Rahman,Fernando Postalli Rodrigues,Aline Sueli de Lima Rodrigues,‪Damià Barceló,Abu Reza Md. Towfiqul Islam,Guilherme Malafaia
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:442: 130004-130004 被引量:41
标识
DOI:10.1016/j.jhazmat.2022.130004
摘要

Although the in vivo toxicity of nanoplastics (NPs) has already been reported in different model systems, their effects on mammalian behavior are poorly understood. Thus, we aimed to evaluate whether exposure to polystyrene (PS) NPs (diameter: 23.03 ± 0.266 nm) alters the behavior (locomotor, anxiety-like and antipredator) of male Swiss mice, induces brain antioxidant activity, and erythrocyte DNA damage. For this, the animals were exposed to NPs for 20 days at different doses (6.5 ng/kg and 6500 ng/kg). Initially, we did not observe any effect of pollutants on the locomotor activity of the animals (inferred via open field test and Basso mouse scale for locomotion). However, we noticed an anxiolytic-like behavior (in the open field test) and alterations in the antipredatory defensive response of mice exposed to PS NPs, when confronted with their predator potential (snake, Pantherophis guttatus). Furthermore, such changes were associated with suppressing brain antioxidant activity, inferred by lower DPPH radical scavenging activity, reduced total glutathione content, as well as the translocation and accumulation of NPs in the brain of the animals. In addition, we noted that the treatments induced DNA damage, evaluated via a single-cell gel electrophoresis assay (comet assay) applied to circulating erythrocytes of the animals. However, we did not observe a dose-response effect for all biomarkers evaluated and the estimated accumulation of PS NPs in the brain. The values of the integrated biomarker response index and the results of the principal component analysis (PCA) and the hierarchical clustering analysis confirmed the similarity between the responses of animals exposed to different doses of PS NPs. Therefore, our study sheds light on how PS NPs can impact mammals and reinforce the ecotoxicological risk associated with the dispersion of these pollutants in natural environments and their uptake by mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
狂野傲南发布了新的文献求助10
4秒前
惠惠不会完成签到,获得积分10
6秒前
情怀应助科研通管家采纳,获得10
6秒前
大个应助科研通管家采纳,获得10
6秒前
orixero应助科研通管家采纳,获得20
6秒前
GingerF应助科研通管家采纳,获得50
6秒前
888完成签到 ,获得积分10
8秒前
charming完成签到,获得积分10
10秒前
糕糕完成签到,获得积分20
10秒前
星辰大海应助狂野傲南采纳,获得10
11秒前
11秒前
13秒前
16秒前
奋斗的萝发布了新的文献求助20
17秒前
余银鹏发布了新的文献求助10
21秒前
狂野傲南完成签到,获得积分10
21秒前
21秒前
charming发布了新的文献求助10
25秒前
26秒前
31秒前
117完成签到,获得积分10
32秒前
乐乐应助一区种子选手采纳,获得10
33秒前
fanfan完成签到 ,获得积分20
33秒前
Liufgui完成签到,获得积分0
34秒前
贪玩小小完成签到 ,获得积分10
35秒前
36秒前
41秒前
Rondab应助高贵的雅山采纳,获得10
45秒前
Claudia完成签到 ,获得积分10
45秒前
英姑应助欧啦啦采纳,获得10
45秒前
47秒前
充电宝应助如意的冰双采纳,获得10
50秒前
橘橘橘子皮完成签到 ,获得积分10
53秒前
54秒前
上官若男应助儒雅小班采纳,获得100
55秒前
量子星尘发布了新的文献求助10
57秒前
哔噗哔噗完成签到 ,获得积分10
58秒前
1分钟前
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4007663
求助须知:如何正确求助?哪些是违规求助? 3547604
关于积分的说明 11298425
捐赠科研通 3282733
什么是DOI,文献DOI怎么找? 1810173
邀请新用户注册赠送积分活动 885950
科研通“疑难数据库(出版商)”最低求助积分说明 811181