The prevalence and influencing factors of cognitive frailty in patients with maintenance hemodialysis in China: a meta-analysis

Abstract Objective :To investigate the prevalence and influencing factors. Methods : CNKI, VIP, Wanfang Data Knowledge Service platform(Wanfang), China Biomedical Literature Database (CBM), PubMed, Embase, Cochrane Library, Web of Science were searched. Cross-sectional studies, case-control studies, and cohort studies on factors influencing cognitive frality in maintenance hemodialysis patients were collected and published between 2000 and October 2023. Two researchers independently screened literature and extracted data to evaluate the literature quality of the included studies. Stata15.0 software was used to conduct a meta-analysis on the prevalence and influencing factors of cognitive frailty in maintenance hemodialysis patients in China. Results : A total of 10 literatures on cognitive frailty were included in this study, including 659 patients with cognitive frailty, involving 25 influencing factors. The results of meta-analysis showed that the prevalence of cognitive frailty in maintenance hemodialysis patients in China was 25.6% (95% CI: 21%~30.3%). Age ( OR =0.542,95% CI (0.294, 0.789), P <0.001), education level ( OR =-1.556,95% CI (-2.113, -1.000), P <0.001), comorbidities ( OR =0.909,95% CI (0.295, 1.524), P =0.004], stroke history ( OR =1.046, 95% CI (0.509, 1.5834), P <0.001) were the influential factors for cognitive frailty in maintenance hemodialysis patients in China. Conclusion : The prevalence rate of cognitive frailty in maintenance hemodialysis patients in China is high (25.6%), and age, educational level, comorbidities and stroke history are the influencing factors of cognitive frailty in maintenance hemodialysis patients in China.