苯并噻二嗪
化学
催化作用
区域选择性
钯
硫黄
组合化学
功能群
氧化磷酸化
二氧化硫
有机化学
生物化学
聚合物
作者
Zhenjie Qi,Simiaomiao Wen,Li Hao,Shuai Liu,Jiang Dong-fang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-10-04
卷期号:25 (40): 7322-7326
标识
DOI:10.1021/acs.orglett.3c02683
摘要
A simple and efficient Pd-catalyzed oxidative cyclization system is developed for the chemo- and regioselective synthesis of 3,4-dihydro-benzothiadiazine 1,1-dioxides, which are formed through aminosulfonylation of ortho-iodoanilines with SO2. DABSO is utilized as the source of SO2, and the organic compound O2 acts as an oxidant. This direct C-S, S-N, and C-N functionalization is highly efficient, and broad functional group tolerance is observed, resulting in moderate to excellent yields of 3,4-dihydro-benzothiadiazine 1,1-dioxides. Furthermore, this method is amenable to gram-scale synthesis.
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