Assembly of Metal–Phenolic Networks onto Microbubbles for One‐Step Generation of Functional Microcapsules

Abstract The one‐step assembly of metal–phenolic networks (MPNs) onto particle templates can enable the facile, rapid, and robust construction of hollow microcapsules. However, the required template removal step may affect the refilling of functional species in the hollow interior space or the in situ encapsulation of guest molecules during the formation of the shells. Herein, a simple strategy for the one‐step generation of functional MPNs microcapsules is proposed. This method uses bovine serum albumin microbubbles (BSA MBs) as soft templates and carriers, enabling the efficient pre‐encapsulation of guest species by leveraging the coordination assembly of tannic acid (TA) and Fe III ions. The addition of TA and Fe III induces a change in the protein conformation of BSA MBs and produces semipermeable capsule shells, which allow gas to escape from the MBs without template removal. The MBs‐templated strategy can produce highly biocompatible capsules with controllable structure and size, and it is applicable to produce other MPNs systems like BSA‐TA‐Cu II and BSA‐TA‐Ni II . Finally, those MBs‐templated MPNs capsules can be further functionalized or modified for the loading of magnetic nanoparticles and the pre‐encapsulation of model molecules through covalence or physical adsorption, exhibiting great promise in biomedical applications.