作者
Cristina Muniesa Montserrat,Fernando Gallardo,I. García‐Doval,M.T. Estrach,Andrea Combalía,M. Morillo‐Andújar,F. De la Cruz‐Vicente,Salma Machan,Cristina Moya‐Martínez,R. Rovira,B. Sanchez‐Gonzalez,Elvira Acebo,Elena Amutio,Yeray Peñate,M. Carmen Losada-Castillo,M.P. García-Muret,Helena Iznardo,Concépción Román-Curto,Javier Cañueto,Ricardo Fernández-de-Misa,Ángeles Flórez,R. Izu,Ignacio Torres‐Navarro,Ana Zayas,G. Pérez‐Paredes,Mar Blanes,José I. Yanguas,A. Pérez‐Ferriols,Marta Callejas-Charavia,Pablo L. Ortiz‐Romero,Amalia Pérez‐Gil,Lucía Prieto‐Torres,Eva González‐Barca,Octavio Servitje
摘要
Brentuximab vedotin (BV) has been approved for CD30-expressing cutaneous T-cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited.To evaluate the response and tolerance of BV in a cohort of patients with CTCL.We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP).Sixty-seven patients were included. There were 26 females and the mean age at diagnosis was 59 years. Forty-eight were mycosis fungoides (MF), 7 Sézary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow-up was 18 months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8 months. During follow-up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3 months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2.These results confirm the efficacy and safety of BV in patients with advanced-stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases.