医学
危险系数
前瞻性队列研究
内科学
比例危险模型
置信区间
C反应蛋白
死因
队列研究
队列
百分位
人口学
炎症
疾病
统计
数学
社会学
作者
Solim Essomandan Clémence Bafei,Yang Song,Changying Chen,Xincheng Gu,Jialing Mu,Fangyuan Liu,Jwo‐Shiun Sun,Qian Zhang,Pengfei Wei,Xin Zhao,Yanchun Chen,You Yin,Hongwei Xie,Chong Shen
标识
DOI:10.1016/j.mad.2023.111804
摘要
To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified. Among men, the smoothed centile curves of hs-CRP gradually increased from age 35 onwards whereas, the smoothed centile curves of hs-CRP continuously increased as age increased among women. Compared with the reference group, the adjusted HR of the association between elevated hs-CRP and all-cause death was 1.33 (95 % CI: 1.11-1.61). The adjusted HRs of the associations between elevated hs-CRP and all-cause death were higher in women [1.40 (95 % CI: 1.07-1.83)] than men [1.28 (95 % CI: 0.99-1.65) and in subjects aged < 65 years [1.77 (95 % CI: 1.19-2.62)] than in subjects aged ≥ 65 years [1.27 (95 % CI: 1.03-1.57)]. Our findings highlight the need of investigating sex and age differences in biological pathways that link inflammation and mortality.
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