血浆糖原
衰老的大脑
磷脂酰丝氨酸
多不饱和脂肪酸
痴呆
神经科学
医学
生物
认知
生物化学
内科学
疾病
脂肪酸
磷脂
膜
作者
Weixi Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Miao Du,Jiazeng Sun,Juan Chen,Yixuan Li,Chongde Sun,Xin Gen Lei,Xue Zhang,Fazheng Ren
标识
DOI:10.1016/j.eng.2023.04.012
摘要
As people live longer, the burden of aging-related brain diseases, especially dementia, is increasing. Brain aging increases the risk of cognitive impairment, which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid homeostasis. Therefore, supplemental dietary lipids have the potential to prevent brain aging. This review summarizes the important roles of dietary lipids in brain function from both structure and mechanism perspectives. Epidemiological and animal studies have provided evidence of the functions of polyunsaturated fatty acids (PUFAs) in brain health. The results of interventions indicate that phospholipids—including phosphatidylcholine, phosphatidylserine, and plasmalogen—are efficient in alleviating cognitive impairment during aging, with plasmalogen exhibiting higher efficacy than phosphatidylserine. Plasmalogen is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of neurons. Future research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.
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