医学
神经学
碱性成纤维细胞生长因子
格林-巴利综合征
发病机制
多神经根神经病
炎症
慢性炎症性脱髓鞘性多发性神经病
血管内皮生长因子
神经内膜
免疫学
内科学
促炎细胞因子
抗体
生长因子
受体
血管内皮生长因子受体
精神科
坐骨神经
作者
Sambit Dash,Ullas Kamath,Aparna R Pai,Pragna Rao
出处
期刊:Neurology India
[Medknow Publications]
日期:2022-11-11
卷期号:70 (5): 2082-2085
标识
DOI:10.4103/0028-3886.359238
摘要
Guillain Barre syndrome (GBS) is an immune-mediated peripheral neuropathy characterized by the demyelination and axonal damage of the peripheral neurons. The pathogenesis of GBS involves the breakdown of the blood-brain barrier after which pro inflammatory cytokines attack the neurons in the peripheral nervous system.This study aims to evaluate five markers, namely matrix metalloproteinase (MMP)-2 and MMP-9, vascular endothelial growth factor (VEGF)-A, basic fibroblast growth factor (bFGF), and SFLT-1, which could have a role in the inflammatory response in patients with GBS and healthy controls.In this prospective study, patients diagnosed with GBS at the department of neurology, Kasturba Medical College, Manipal, Karnataka were enrolled.The markers selected for this study were analyzed using the ELISA method and expressed as given in the kit provided by the company. Ethical clearance was obtained from the Institutional Ethical Committee.Results were evaluated using SPSS version 17.0 and expressed as mean ± SD. Error bars for each were drawn.The levels of all five parameters showed a significant increase in patients as compared to controls.Disruption of the basement membrane of endoneurium by MMP-2 and MMP-9, recruitment and migration of macrophages and other cytokines by VEGF-A, bFGF, and soluble fms-like tyrosine kinase-1 (SFLT-1) are plausible, which leads to inflammation process and thus neuronal damage leading to the development of GBS.
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