烟碱激动剂
乙酰胆碱受体
胆碱能的
乙酰胆碱
炎症
神经科学
受体
化学
药理学
烟碱乙酰胆碱受体
医学
生物
免疫学
生物化学
作者
Arik J. Hone,J. Michael McIntosh
标识
DOI:10.1016/j.phrs.2023.106715
摘要
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated in immune cells. Furthermore, the signaling pathways where nAChRs are expressed can be activated by endogenous ligands other than the canonical agonists acetylcholine and choline. In this review, we discuss the involvement of a subset of nAChRs containing α7, α9, and/or α10 subunits in the modulation of pain and inflammation via the cholinergic anti-inflammatory pathway. Additionally, we review the most recent advances in the development of novel ligands and their potential as therapeutics.
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